2 papers
physics.chem-ph2004
A general expression for bimolecular association rates with orientational constraints
Maximilian Schlosshauer, David Baker
We present a general expression for the association rate for partially diffusion-controlled reactions between spherical molecules with an asymmetric reactive patch on each surface.…
q-bio.BM2004
Realistic protein-protein association rates from a simple diffusional model neglecting long-range interactions, free energy barriers, and landscape ruggedness
Maximilian Schlosshauer, David Baker
We develop a simple but rigorous model of protein-protein association kinetics based on diffusional association on free energy landscapes obtained by sampling configurations within…