5 papers
The typical red cell makes too little vacuole material for coalescence to build the large vacuoles of pocked cells
Zhaojie Chai, Jianlu Zheng, He Li +2
Red blood cells carrying intracellular vacuoles, called pocked cells, are a sensitive marker of splenic function: about 0.5% of cells in healthy people, 20 to 70% after splenectomy…
Quantifying the Biophysical Properties of Red Blood Cells in Gaucher Disease
Zhaojie Chai, Marine de Person, Pierre A. Buffet +2
Gaucher disease (GD), the most common lysosomal storage disorder, alters red blood cell (RBC) mechanics and circulation, contributing to vascular occlusions, bone infarcts, and spl…
Quantifying reticulocyte biomechanics in health and disease
Zhaojie Chai, Jianlu Zheng, He Li +2
Red blood cell (RBC) populations are mechanically and morphologically heterogeneous, yet how this heterogeneity governs transport, splenic retention and blood rheology in confineme…
Quantifying the biophysical properties of stomatocytes in health and disease
Zhaojie Chai, Jianlu Zheng, He Li +2
Hereditary stomatocytosis (HS) comprises red blood cell (RBC) disorders characterized by cup-shaped erythrocytes that respond oppositely to splenectomy: curative in overhydrated HS…
GRAFT-ATHENA: Self-Improving Agentic Teams for Autonomous Discovery and Evolutionary Numerical Algorithms
Juan Diego Toscano, Zhaojie Chai, George Em Karniadakis
Language-model agents plan, execute, and evaluate scientific workflows. However, the problem--method relationships guiding their choices remain implicit, so plausible outputs can v…