4 papers
Quantifying the Biophysical Properties of Red Blood Cells in Gaucher Disease
Zhaojie Chai, Marine de Person, Pierre A. Buffet +2
Gaucher disease (GD), the most common lysosomal storage disorder, alters red blood cell (RBC) mechanics and circulation, contributing to vascular occlusions, bone infarcts, and spl…
Quantifying reticulocyte biomechanics in health and disease
Zhaojie Chai, Jianlu Zheng, He Li +2
Red blood cell (RBC) populations are mechanically heterogeneous, yet how this shapes transport, clogging, and rheology in confined environments remains unclear. We combine microflu…
Quantifying the biophysical properties of stomatocytes in health and disease
Zhaojie Chai, Jianlu Zheng, He Li +2
Hereditary stomatocytosis (HS) comprises red blood cell (RBC) disorders characterized by cup-shaped erythrocytes that respond oppositely to splenectomy: curative in overhydrated HS…
GRAFT-ATHENA: Self-Improving Agentic Teams for Autonomous Discovery and Evolutionary Numerical Algorithms
Juan Diego Toscano, Zhaojie Chai, George Em Karniadakis
Scientific methods are developed for classes of problems, so knowledge transfers across structurally related cases. Language-model agents can execute scientific workflows, but thei…