2 papers
math.DS2026
Decoding gene regulatory networks from single-cell RNA velocity
Lingqi Meng, Shiruo Wang
We formulate gene regulatory network reconstruction from RNA velocity as a sparse dynamical inverse problem. We show that control-only data can be structurally nonidentifying and c…
math.ST2026
A statistical theory of graph regularization for RNA velocity near developmental bifurcations
Lingqi Meng, Shiruo Wang
Graph-based regularization is widely used to stabilize noisy RNA-velocity estimates by encouraging transcriptionally similar cells to share similar velocity vectors. Near developme…