2 papers
stat.ME2026
Meta-analysis and network meta-analysis of time-to-event outcomes with non-proportional hazards: a Bayesian time-varying hazard ratio approach
Rhiannon K Owen, Keith R Abrams
Background: Often when undertaking meta-analyses of time-to-event (TTE) outcomes, especially in a Health Technology Assessment context, a hazard ratio (HR) scale is used. However,…
stat.ME2025
Bayesian joint modelling of longitudinal biomarkers to enable extrapolation of overall survival: an application using larotrectinib trial clinical data
Louise Linsell, Noman Paracha, Jamie Grossman +7
Objectives To investigate the use of a Bayesian joint modelling approach to predict overall survival (OS) from immature clinical trial data using an intermediate biomarker. To comp…