91 citations · 658 across the 28 of their papers we have counts for
8 papers · 1 filter
Modelling the effect of curvature on the collective behaviour of cells growing new tissue
Almie Alias, Pascal R Buenzli
The growth of several biological tissues is known to be controlled in part by local geometrical features, such as the curvature of the tissue interface. This control leads to chang…
Governing equations of tissue modelling and remodelling: A unified generalised description of surface and bulk balance
Pascal R. Buenzli
Several biological tissues undergo changes in their geometry and in their bulk material properties by modelling and remodelling processes. Modelling synthesises tissue in some regi…
A multiscale mechanobiological model of bone remodelling predicts site-specific bone loss in the femur during osteoporosis and mechanical disuse
C. Lerebours, P. R. Buenzli, S. Scheiner +1
We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model inc…
Bone refilling in cortical bone multicellular units: Insights into tetracycline double labelling from a computational model
Pascal R. Buenzli, Peter Pivonka, David W. Smith
Bone remodelling is carried out by `bone multicellular units' (BMUs) in which active osteoclasts and active osteoblasts are spatially and temporally coupled. The refilling of new b…
The influence of bone surface availability in bone remodelling - A mathematical model including coupled geometrical and biomechanical regulations of bone cells
Peter Pivonka, Pascal R. Buenzli, Stefan Scheiner +2
Bone is a biomaterial undergoing continuous renewal. The renewal process is known as bone remodelling and is operated by bone-resorbing cells (osteoclasts) and bone-forming cells (…
Modelling the anabolic response of bone using a cell population model
Pascal R. Buenzli, Peter Pivonka, Bruce S. Gardiner +1
To maintain bone mass during bone remodelling, coupling is required between bone resorption and bone formation. This coordination is achieved by a network of autocrine and paracrin…