46 citations · 160 across the 11 of their papers we have counts for
14 papers
Resolving non-equilibrium shape variations amongst millions of gold nanoparticles
Zhou Shen, Salah Awel, Anton Barty +36
Nanoparticles, exhibiting functionally relevant structural heterogeneity, are at the forefront of cutting-edge research. Now, high-throughput single-particle imaging (SPI) with x-r…
3D-Printed Sheet Jet for Stable Megahertz Liquid Sample Delivery at X-ray Free Electron Lasers
Patrick E. Konold, Tong You, Johan Bielecki +23
X-ray Free Electron Lasers (XFELs) can probe chemical and biological reactions as they unfold with unprecedented spatial and temporal resolution. A principal challenge in this purs…
Unsupervised learning approaches to characterize heterogeneous samples using X-ray single particle imaging
Yulong Zhuang, Salah Awel, Anton Barty +39
One of the outstanding analytical problems in X-ray single particle imaging (SPI) is the classification of structural heterogeneity, which is especially difficult given the low sig…
A Metropolis Monte Carlo Algorithm for Merging Single-Particle Diffraction Intensities
B. R. Mobley, K. E. Schmidt, J. P. Chen +1
Single-particle imaging with X-ray free-electron lasers depends crucially on algorithms that merge large numbers of weak diffraction patterns despite missing measurements of parame…
Optical funnel to guide and focus virus particles for X-ray laser imaging
Salah Awel, Sebastian Lavin-Varela, Nils Roth +5
The need for precise manipulation of nanoparticles in gaseous or near-vacuum environments is encountered in many studies that include aerosol morphology, nanodroplet physics, nanos…
A new solution to the curved Ewald sphere problem for 3D image reconstruction in electron microscopy
J. P. J. Chen, K. E. Schmidt, J. C. H. Spence +1
We develop an algorithm capable of imaging a three-dimensional object given a collection of two-dimensional images of that object that are significantly influenced by the curvature…
New aerodynamic lens injector for single particle diffractive imaging
Nils Roth, Daniel A. Horke, Jannik Lübke +17
An aerodynamic lens injector was developed specifically for the needs of single-particle diffractive imaging experiments at free-electron lasers. Its design allows for quick change…
3D diffractive imaging of nanoparticle ensembles using an X-ray laser
Kartik Ayyer, P. Lourdu Xavier, Johan Bielecki +34
We report the 3D structure determination of gold nanoparticles (AuNPs) by X-ray single particle imaging (SPI). Around 10 million diffraction patterns from gold nanoparticles were m…
An advanced workflow for single particle imaging with the limited data at an X-ray free-electron laser
Dameli Assalauova, Young Yong Kim, Sergey Bobkov +25
An improved analysis for single particle imaging (SPI) experiments, using the limited data, is presented here. Results are based on a study of bacteriophage PR772 performed at the…
Megahertz single-particle imaging at the European XFEL
Egor Sobolev, Serguey Zolotarev, Klaus Giewekemeyer +60
The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimenta…
Low-signal limit of X-ray single particle imaging
Kartik Ayyer, Andrew J. Morgan, Andrew A. Aquila +7
An outstanding question in X-ray single particle imaging experiments has been the feasibility of imaging sub 10-nm-sized biomolecules under realistic experimental conditions where…
Femtosecond x-ray diffraction from an aerosolized beam of protein nanocrystals
Salah Awel, Richard A. Kirian, Max O. Wiedorn +22
We demonstrate near-atomic-resolution Bragg diffraction from aerosolized single granulovirus crystals using an x-ray free-electron laser. The form of the aerosol injector is nearly…
Visualizing aerosol-particle injection for diffractive-imaging experiments
Salah Awel, Richard A. Kirian, Niko Eckerskorn +5
Delivering sub-micrometer particles to an intense x-ray focus is a crucial aspect of single-particle diffractive-imaging experiments at x-ray free-electron lasers. Enabling direct…
Tomographic femtosecond X-ray diffractive imaging
K. E. Schmidt, J. C. H. Spence, U. Weierstall +6
A method is proposed for obtaining three simultaneous projections of a target from a single radiation pulse, which also allows the relative orientation of successive targets to be…