151 citations · 956 across the 18 of their papers we have counts for
3 papers · 1 filter
Epistasis can lead to fragmented neutral spaces and contingency in evolution
Steffen Schaper, Iain G. Johnston, Ard A. Louis
In evolution, the effects of a single deleterious mutation can sometimes be compensated for by a second mutation which recovers the original phenotype. Such epistatic interactions…
Mitochondrial Variability as a Source of Extrinsic Cellular Noise
Iain G. Johnston, Bernadett Gaal, Ricardo Pires das Neves +3
We present a study investigating the role of mitochondrial variability in generating noise in eukaryotic cells. Noise in cellular physiology plays an important role in many fundame…
Evolutionary Dynamics in a Simple Model of Self-Assembly
Iain G. Johnston, Sebastian A. Ahnert, Jonathan P. K. Doye +1
We investigate the evolutionary dynamics of an idealised model for the robust self-assembly of two-dimensional structures called polyominoes. The model includes rules that encode i…