151 citations · 956 across the 18 of their papers we have counts for
5 papers · 1 filter
Phenotypic landscape inference reveals multiple evolutionary paths to C photosynthesis
Ben P. Williams, Iain G. Johnston, Sarah Covshoff +1
C photosynthesis has independently evolved from the ancestral C pathway in at least 60 plant lineages, but, as with other complex traits, how it evolved is unclear. Here we…
A tractable genotype-phenotype map for the self-assembly of protein quaternary structure
Sam F. Greenbury, Iain G. Johnston, Ard A. Louis +1
The mapping between biological genotypes and phenotypes is central to the study of biological evolution. Here we introduce a rich, intuitive, and biologically realistic genotype-ph…
Epistasis can lead to fragmented neutral spaces and contingency in evolution
Steffen Schaper, Iain G. Johnston, Ard A. Louis
In evolution, the effects of a single deleterious mutation can sometimes be compensated for by a second mutation which recovers the original phenotype. Such epistatic interactions…
Evolutionary Dynamics in a Simple Model of Self-Assembly
Iain G. Johnston, Sebastian A. Ahnert, Jonathan P. K. Doye +1
We investigate the evolutionary dynamics of an idealised model for the robust self-assembly of two-dimensional structures called polyominoes. The model includes rules that encode i…
The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks
Sam F. Greenbury, Iain G. Johnston, Matthew A. Smith +2
We investigate how scale-free (SF) and Erdos-Renyi (ER) topologies affect the interplay between evolvability and robustness of model gene regulatory networks with Boolean threshold…