Predicting clinical significance of BRCA1 and BRCA2 single nucleotide substitution variants with unknown clinical significance using probabilistic neural network and deep neural network-stacked autoencoder

Ehsan Rahmatizad KhajePasha, Mahdi Bazarghan, Hamidreza Kheiri Manjili +2

Non-synonymous single nucleotide polymorphisms (nsSNPs) are single nucleotide substitution occurring in the coding region of a gene and leads to a change in amino-acid sequence of…