4 papers · 1 filter
On Cluster Randomized Trials with the Desirability of Outcome Ranking (DOOR) Endpoints
Wanying Shao, Toshimitsu Hamasaki, Scott Evans +1
Cluster randomized trials are widely used when individual randomization is logistically infeasible or when correlations between observations cannot be ignored, especially in fields…
Navigating the Landscape of Hierarchical Multi-Component Strategies: GPC, DOOR, and MOST
Mickaël De Backer, Johan Verbeeck, Vivian Lanius +5
There is a growing recognition of the importance to involve patients in every stage of drug development. This shift acknowledges that patients' perspectives, experiences, and prefe…
Doubly Robust Estimation of Desirability of Outcome Ranking (DOOR) Probability with Application to MDRO Studies
Shiyu Shu, Toshimitsu Hamasaki, Scott Evans +3
In observational studies, adjusting for confounders is required if a treatment comparison is planned. A crude comparison of the primary endpoint without covariate adjustment will s…
Desirability of outcome ranking (DOOR) analysis for multivariate survival outcomes with application to ACTT-1 trial
Shiyu Shu, Guoqing Diao, Toshimitsu Hamasaki +1
Desirability Of Outcome Ranking (DOOR) methodology accounts for problems that conventional benefit:risk analyses in clinical trials ignore, such as competing risks and the trade-of…