392 citations · 2.2k across the 33 of their papers we have counts for
6 papers · 1 filter
The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents
Thomas M McGrath, Eleanor Spreckley, Aina Fernandez Rodriguez +5
Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour.…
Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism
Iain G. Johnston, Joerg P. Burgstaller, Vitezslav Havlicek +5
Dangerous damage to mitochondrial DNA (mtDNA) can be ameliorated during mammalian development through a highly debated mechanism called the mtDNA bottleneck. Uncertainty surroundin…
Closed-form stochastic solutions for non-equilibrium dynamics and inheritance of cellular components over many cell divisions
Iain G. Johnston, Nick S. Jones
Stochastic dynamics govern many important processes in cellular biology, and an underlying theoretical approach describing these dynamics is desirable to address a wealth of questi…
Explicit tracking of uncertainty increases the power of quantitative rule-of-thumb reasoning in cell biology
Iain G. Johnston, Benjamin C. Rickett, Nick S. Jones
"Back-of-the-envelope" or "rule-of-thumb" calculations involving rough estimates of quantities play a central scientific role in developing intuition about the structure and behavi…
Evolutionary Inference for Function-valued Traits: Gaussian Process Regression on Phylogenies
Nick S. Jones, John Moriarty
Biological data objects often have both of the following features: (i) they are functions rather than single numbers or vectors, and (ii) they are correlated due to phylogenetic re…
Rapidly detecting disorder in rhythmic biological signals: A spectral entropy measure to identify cardiac arrhythmias
Phillip P. A. Staniczenko, Chiu Fan Lee, Nick S. Jones
We consider the use of a running measure of power spectrum disorder to distinguish between the normal sinus rhythm of the heart and two forms of cardiac arrhythmia: atrial fibrilla…