40 citations · 98 across the 6 of their papers we have counts for
6 papers
Characterizing the folding core of the cyclophilin A - cyclosporin A complex II: improving folding core predictions by including mobility
J. W. Heal, S. A. Wells, R. B. Freedman +1
Determining the folding core of a protein yields information about its folding process and dynamics. The experimental procedures for identifying the amino acids which make up the f…
Characterizing the folding core of the cyclophilin A - cyclosporin A complex I: hydrogen exchange data and rigidity analysis
J. W. Heal, R. A. Römer, C. A. Blindauer +1
The determination of a 'folding core' can help to provide insight into the structure, flexibility, mobility and dynamics, and hence, ultimately, function of a protein - a central c…
The dynamics and flexibility of protein disulphide-isomerase (PDI): predictions of experimentally-observed domain motions
J Emilio Jimenez-Roldan, Moitrayee Bhattacharyya, Stephen A Wells +3
We have studied the mobility of the folding catalyst, protein disulphide-isomerase (PDI), by molecular dynamics and by a rapid approach based on flexibility. We analysed our simula…
The interplay of mutations and electronic properties in disease-related genes
Chi-Tin Shih, Stephen A. Wells, Ching-Ling Hsu +2
Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycos…
Exploring the Energy Landscapes of Protein Folding Simulations with Bayesian Computation
Nikolas S. Burkoff, Csilla Varnai, Stephen A. Wells +1
Nested sampling is a Bayesian sampling technique developed to explore probability distributions lo- calised in an exponentially small area of the parameter space. The algorithm pro…
Sensitivity of protein rigidity analysis to small structural variations: a large-scale comparative analysis
Stephen A. Wells, J. Emilio Jimenez-Roldan, Rudolf A. Römer
Rigidity analysis using the "pebble game" can usefully be applied to protein crystal structures to obtain information on protein folding, assembly and the structure-function relati…