3 papers
math.DS2026
Learning dynamical systems with biochemically informed neural ordinary differential equations
Luis L. Fonseca, Reinhard C. Laubenbacher, Lucas Böttcher
Ordinary differential equation models of biochemical reactions are often formulated as stoichiometric systems in which the dynamics arise from a collection of interacting processes…
stat.ME2025
EFECT: A Method to Quantify the Reproducibility of Stochastic Simulations
T. J. Sego, Matthias König, Luis L. Fonseca +13
Reproducibility is a fundamental requirement for validating scientific claims in computational research. Stochastic computational models are widely used in fields such as systems b…
q-bio.QM2024
Surrogate Modeling and Control of Medical Digital Twins
Luis L. Fonseca, Lucas Böttcher, Borna Mehrad +1
The vision of personalized medicine is to identify interventions that maintain or restore a person's health based on their individual biology. Medical digital twins, computational…