2 papers
q-bio.BM2026
An accurate nucleic acid-small molecule docking framework via geometric deep learning with large-scale pretraining
Shi Li, Xujun Zhang, Mingquan Liu +5
Nucleic acids are increasingly recognized as therapeutic targets beyond conventional protein-centered drug discovery, yet accurate and efficient docking of small molecules to nucle…
q-bio.BM2025
Discovery of novel antimicrobial peptides with notable antibacterial potency by a LLM-based foundation model
Jike Wang, Jianwen Feng, Yu Kang +16
Large language models (LLMs) have shown remarkable advancements in chemistry and biomedical research, acting as versatile foundation models for various tasks. We introduce AMP-Desi…