78 citations · 93 across the 3 of their papers we have counts for
3 papers
Biological control networks suggest the use of biomimetic sets for combinatorial therapies
Jacob D. Feala, Jorge Cortes, Phillip M. Duxbury +3
Cells are regulated by networks of controllers having many targets, and targets affected by many controllers, but these "many-to-many" combinatorial control systems are poorly unde…
Metabolomic and flux-balance analysis of age-related decline of hypoxia tolerance in Drosophila muscle tissue
Laurence Coquin, Jacob D. Feala, Andrew D. McCulloch +1
The fruit fly D. melanogaster is increasingly used as a model organism for studying acute hypoxia tolerance and for studying aging, but the interactions between these two factors a…
Search algorithms as a framework for the optimization of drug combinations
Diego Calzolari, Stefania Bruschi, Laurence Coquin +5
Combination therapies are often needed for effective clinical outcomes in the management of complex diseases, but presently they are generally based on empirical clinical experienc…