79 citations · 240 across the 13 of their papers we have counts for
5 papers · 1 filter
How proteins squeeze through polymer networks: a Cartesian lattice study
Annika Wedemeier, Holger Merlitz, Chen-Xu Wu +1
In this paper a lattice model for the diffusional transport of particles in the interphase cell nucleus is proposed. The dynamic behaviour of single chains on the lattice is invest…
Modelling diffusional transport in the interphase cell nucleus
Annika Wedemeier, Holger Merlitz, Chen-Xu Wu +1
In this paper a lattice model for diffusional transport of particles in the interphase cell nucleus is proposed. Dense networks of chromatin fibers are created by three different m…
Facilitated diffusion of DNA-binding proteins: Simulation of large systems
Holger Merlitz, Konstantin V. Klenin, Chen-Xu Wu +1
The recently introduced method of excess collisions (MEC) is modified to estimate diffusion-controlled reaction times inside systems of arbitrary size. The resulting MEC-E equation…
Facilitated diffusion of DNA-binding proteins: Efficient simulation with the method of excess collisions (MEC)
Holger Merlitz, Konstantin V. Klenin, Chen-Xu Wu +1
In this paper, a new method to efficiently simulate diffusion controlled second order chemical reactions is derived and applied to site-specific DNA-binding proteins. The protein e…
Facilitated diffusion of DNA-binding proteins
Konstantin V. Klenin, Holger Merlitz, Joerg Langowski +1
The diffusion-controlled limit of reaction times for site-specific DNA-binding proteins is derived from first principles. We follow the generally accepted concept that a protein pr…