178 citations · 873 across the 18 of their papers we have counts for
5 papers · 1 filter
Slow fluctuations shape cell signaling near a bifurcation in embryonic stem cells
Fiorella Fabris, Dhruv Raina, Christian Schröter +1
Excitable and oscillatory responses are widespread in cell signaling, but how these arise in the same system is unclear. We propose a minimal model of a saddle node bifurcation on…
Multiple Notch ligands in the synchronization of the segmentation clock
Marcos Wappner, Koichiro Uriu, Andrew C. Oates +1
Notch signaling is a ubiquitous and versatile intercellular signaling system that drives collective behaviors and pattern formation in biological tissues. During embryonic developm…
Effective description of bistability and irreversibility in apoptosis
Sol M. Fernández Arancibia, Hernán E. Grecco, Luis G. Morelli
Apoptosis is a mechanism of programmed cell death in which cells engage in a controlled demolition and prepare to be digested without damaging their environment. In normal conditio…
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression
Iván M. Lengyel, Luis G. Morelli
Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studie…
Delayed coupling theory of vertebrate segmentation
Luis G. Morelli, Saul Ares, Leah Herrgen +3
Rhythmic and sequential subdivision of the elongating vertebrate embryonic body axis into morphological somites is controlled by an oscillating multicellular genetic network termed…