5 papers
Evaluating Efficiency of Platform Trials Under Delayed Outcomes Using Treatment Throughput
Aritra Mukherjee, James M. S. Wason
Background: Platform trials improve efficiency by enabling early stopping of ineffective arms, shared controls, and addition of new treatments without compromising statistical prop…
Comparing Bayesian Dynamic Borrowing and Synthetic Control Methods: Apples to Oranges?
Nicole Cizauskas, Foteini Strimenopoulou, Svetlana S. Cherlin +1
Bayesian dynamic borrowing (BDB) and synthetic control methods (SCM) are strategies to incorporate historical data in clinical trial design when control recruitment is a challenge.…
Augmented Binary Method for Basket Trials (ABBA)
Svetlana Cherlin, James M S Wason
In several clinical areas, traditional clinical trials often use a responder outcome, a composite endpoint that involves dichotomising a continuous measure. An augmented binary met…
Optimal Bayesian stepped-wedge cluster randomised trial designs for binary outcome data
Laura Etfer, James M. S. Wason, Michael J. Grayling
Under a generalised estimating equation analysis approach, approximate design theory is used to determine Bayesian D-optimal designs. For two examples, considering simple exchangea…
Bayesian sample size determination using robust commensurate priors with interpretable discrepancy weights
Lou E. Whitehead, James M. S. Wason, Oliver Sailer +1
Randomized controlled clinical trials provide the gold standard for evidence generation in relation to the efficacy of a new treatment in medical research. Relevant information fro…