1.6k citations · 1.6k across the 3 of their papers we have counts for
5 papers
On Periodic Reference Tracking Using Batch-Mode Reinforcement Learning with Application to Gene Regulatory Network Control
Aivar Sootla, Natalja Strelkowa, Damien Ernst +2
In this paper, we consider the periodic reference tracking problem in the framework of batch-mode reinforcement learning, which studies methods for solving optimal control problems…
Toggling a Genetic Switch Using Reinforcement Learning
Aivar Sootla, Natalja Strelkowa, Damien Ernst +2
In this paper, we consider the problem of optimal exogenous control of gene regulatory networks. Our approach consists in adapting an established reinforcement learning algorithm c…
Transient dynamics around unstable periodic orbits in the generalized repressilator model
Natalja Strelkowa, Mauricio Barahona
We study the spatio-temporal dynamics of the generalized repressilator, a system of coupled repressing genes arranged in a directed ring topology, and give analytical conditions fo…
Switchable Genetic Oscillator Operating in Quasi-Stable Mode
Natalja Strelkowa, Mauricio Barahona
Ring topologies of repressing genes have qualitatively different long-term dynamics if the number of genes is odd (they oscillate) or even (they exhibit bistability). However, thes…
Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems
Tina Toni, David Welch, Natalja Strelkowa +2
Approximate Bayesian computation methods can be used to evaluate posterior distributions without having to calculate likelihoods. In this paper we discuss and apply an approximate…