9 citations · 9 across the 2 of their papers we have counts for
2 papers
stat.ME2024
BARD: A seamless two-stage dose optimization design integrating backfill and adaptive randomization
Yixuan Zhao, Rachael Liu, Jianchang Lin +1
One common approach for dose optimization is a two-stage design, which initially conducts dose escalation to identify the maximum tolerated dose (MTD), followed by a randomization…
stat.ME2022★ 9 cited
Flexible Seamless 2-in-1 Design with Sample Size Adaptation
Runjia Li, Liwen Wu, Rachael Liu +1
2-in-1 design (Chen et al. 2018) is becoming popular in oncology drug development, with the flexibility of using different endpoints at different decision time. Based on the observ…