Modeling Platelet P2Y${}_1$/${}_{12}$ Pathway to Integrin Activation

Keshav B. Patel, Wolfgang Bergmeier, Aaron L. Fogelson

Through experimental studies, many details of the pathway of integrin ${\alpha }_{\mathrm{IIb}}{\beta }_3$ activation by ADP during the platelet aggregation process have been mapped out. ADP binds to…