2 papers
cs.LG2024
Predicting sub-population specific viral evolution
Wenxian Shi, Menghua Wu, Regina Barzilay
Forecasting the change in the distribution of viral variants is crucial for therapeutic design and disease surveillance. This task poses significant modeling challenges due to the…
q-bio.BM2024
PROflow: An iterative refinement model for PROTAC-induced structure prediction
Bo Qiang, Wenxian Shi, Yuxuan Song +1
Proteolysis targeting chimeras (PROTACs) are small molecules that trigger the breakdown of traditionally ``undruggable'' proteins by binding simultaneously to their targets and deg…