1 citations · 2 across the 3 of their papers we have counts for
3 papers
Randomization-based Inference for MCP-Mod
Lukas Pin, Oleksandr Sverdlov, Frank Bretz +1
Dose selection is critical in pharmaceutical drug development, as it directly impacts therapeutic efficacy and patient safety of a drug. The Generalized Multiple Comparison Procedu…
Testing for similarity of multivariate mixed outcomes using generalised joint regression models with application to efficacy-toxicity responses
Niklas Hagemann, Giampiero Marra, Frank Bretz +1
A common problem in clinical trials is to test whether the effect of an explanatory variable on a response of interest is similar between two groups, e.g. patient or treatment grou…
Monitoring overall survival in pivotal trials in indolent cancers
Thomas R Fleming, Lisa V Hampson, Bharani Bharani-Dharan +7
Indolent cancers are characterized by long overall survival (OS) times. Therefore, powering a clinical trial to provide definitive assessment of the effects of an experimental inte…