activity
20212026
most citedSpectral decomposition of atomic structures in heterogeneous cryo-EM

5 citations · 11 across the 6 of their papers we have counts for

collaborators

7 papers

cs.LG2026

Beyond Unimodal Bases: Pullback Geometry for Multimodal Data

Honglei Brinkmann, Lucas Ng, Georgios Batzolis +3

Data-driven Riemannian geometry provides nonlinear interpolation and geometric representations of high-dimensional data. For these operations to be statistically meaningful, paths…

cs.LG2024

Pullback Flow Matching on Data Manifolds

Friso de Kruiff, Erik Bekkers, Ozan Öktem +2

We propose Pullback Flow Matching (PFM), a novel framework for generative modeling on data manifolds. Unlike existing methods that assume or learn restrictive closed-form manifold…

cs.LG2024

Score-based Pullback Riemannian Geometry: Extracting the Data Manifold Geometry using Anisotropic Flows

Willem Diepeveen, Georgios Batzolis, Zakhar Shumaylov +1

Data-driven Riemannian geometry has emerged as a powerful tool for interpretable representation learning, offering improved efficiency in downstream tasks. Moving forward, it is cr…

q-bio.BM2023

Riemannian geometry for efficient analysis of protein dynamics data

Willem Diepeveen, Carlos Esteve-Yagüe, Jan Lellmann +2

An increasingly common viewpoint is that protein dynamics data sets reside in a non-linear subspace of low conformational energy. Ideal data analysis tools for such data sets shoul…

eess.IV2022★ 5 cited

Spectral decomposition of atomic structures in heterogeneous cryo-EM

Carlos Esteve-Yagüe, Willem Diepeveen, Ozan Öktem +1

We consider the problem of recovering the three-dimensional atomic structure of a flexible macromolecule from a heterogeneous cryo-EM dataset. The dataset contains noisy tomographi…

math.OC2022★ 2 cited

Regularising orientation estimation in Cryo-EM 3D map refinement through measure-based lifting over Riemannian manifolds

Willem Diepeveen, Jan Lellmann, Ozan Öktem +1

Motivated by the trade-off between noise-robustness and data-consistency for joint 3D map reconstruction and rotation estimation in single particle cryogenic-electron microscopy (C…

math.OC2021★ 4 cited

An Inexact Semi-smooth Newton Method on Riemannian Manifolds with Application to Duality-based Total Variation Denoising

Willem Diepeveen, Jan Lellmann

We propose a higher-order method for solving non-smooth optimization problems on manifolds. In order to obtain superlinear convergence, we apply a Riemannian Semi-smooth Newton met…