5 papers
Eigenvectors of the De Bruijn Graph Laplacian: A Natural Basis for the Cut and Cycle Space
Anthony Philippakis, Neil Mallinar, Parthe Pandit +1
We study the Laplacian of the undirected De Bruijn graph over an alphabet of order . While the eigenvalues of this Laplacian were found in 1998 by Delorme and Tillich [1], a…
Prediction-powered Generalization of Causal Inferences
Ilker Demirel, Ahmed Alaa, Anthony Philippakis +1
Causal inferences from a randomized controlled trial (RCT) may not pertain to a target population where some effect modifiers have a different distribution. Prior work studies gene…
Med-Real2Sim: Non-Invasive Medical Digital Twins using Physics-Informed Self-Supervised Learning
Keying Kuang, Frances Dean, Jack B. Jedlicki +4
A digital twin is a virtual replica of a real-world physical phenomena that uses mathematical modeling to characterize and simulate its defining features. By constructing digital t…
Generating Drug Repurposing Hypotheses through the Combination of Disease-Specific Hypergraphs
Ayush Jain, Marie Laure-Charpignon, Irene Y. Chen +2
The drug development pipeline for a new compound can last 10-20 years and cost over 10 billion. Drug repurposing offers a more time- and cost-effective alternative. Computational a…
InstructCV: Instruction-Tuned Text-to-Image Diffusion Models as Vision Generalists
Yulu Gan, Sungwoo Park, Alexander Schubert +2
Recent advances in generative diffusion models have enabled text-controlled synthesis of realistic and diverse images with impressive quality. Despite these remarkable advances, th…