137 citations · 514 across the 11 of their papers we have counts for
11 papers
Intrinsic cell-to-cell variance from experimental single-cell motility data
Anton Klimek, Johannes C. J. Heyn, Debasmita Mondal +5
When analyzing the individual positional dynamics of an ensemble of moving objects, the extracted parameters that characterize the motion of individual objects, such as the mean-sq…
Self-organized homogenization of flow networks
Julien Bouvard, Swarnavo Basu, Charlott Leu +4
From the vasculature of animals to the porous media making up batteries, the core task of flow networks is to transport solutes and perfuse all cells or media equally with resource…
Geometry-sensitive protrusion growth directs confined cell migration
Johannes Flommersfeld, Stefan Stöberl, Omar Shah +2
The migratory dynamics of cells can be influenced by the complex micro-environment through which they move. It remains unclear how the motility machinery of confined cells responds…
Geometry adaptation of protrusion and polarity dynamics in confined cell migration
David B. Brückner, Matthew Schmitt, Alexandra Fink +6
Cell migration in confining physiological environments relies on the concerted dynamics of several cellular components, including protrusions, adhesions with the environment, and t…
Learning the dynamics of cell-cell interactions in confined cell migration
David B. Brückner, Nicolas Arlt, Alexandra Fink +3
The migratory dynamics of cells in physiological processes, ranging from wound healing to cancer metastasis, rely on contact-mediated cell-cell interactions. These interactions pla…
Disentangling the Behavioural Variability of Confined Cell Migration
David B. Brückner, Alexandra Fink, Joachim O. Rädler +1
Cell-to-cell variability is inherent to numerous biological processes, including cell migration. Quantifying and characterizing the variability of migrating cells is challenging, a…
Shear-induced unfolding and enzymatic cleavage of full-length VWF multimers
Svenja Lippok, Matthias Radtke, Tobias Obser +5
Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF within t…
A versatile method to generate multiple types of micropatterns
F. J. Segerer, P. J. F. Röttgermann, S. Schuster +3
Micropatterning techniques have become an important tool for the study of cell behavior in controlled microenvironments. As a consequence, several approaches for the creation of mi…
Timing and dynamics of single cell gene expression in the arabinose utilization system
Judith A. Megerle, Georg Fritz, Ulrich Gerland +2
The arabinose utilization system of E. coli displays a stochastic "all or nothing" response at intermediate levels of arabinose, where the population divides into a fraction catabo…
Development of anomalous diffusion among crowding proteins
Margaret R. Horton, Felix Höfling, Joachim O. Rädler +1
In cell membranes, proteins and lipids diffuse in a highly crowded and heterogeneous landscape, where aggregates and dense domains of proteins or lipids obstruct the path of diffus…
Predictive Modeling of Non-Viral Gene Transfer
Gerlinde Schwake, Simon Youssef, Jan-Timm Kuhr +5
In non-viral gene delivery, the variance of transgenic expression stems from the low number of plasmids successfully transferred. Here, we experimentally determine Lipofectamine- a…