152 citations · 376 across the 6 of their papers we have counts for
7 papers
Dynamic force spectroscopy of DNA hairpins. II. Irreversibility and dissipation
Maria Manosas, Alessandro Mossa, Nuria Forns +2
We investigate irreversibility and dissipation in single molecules that cooperatively fold/unfold in a two state manner under the action of mechanical force. We apply path thermody…
Dynamic force spectroscopy of DNA hairpins. I. Force kinetics and free energy landscapes
Alessandro Mossa, Maria Manosas, Nuria Forns +2
We investigate the thermodynamics and kinetics of DNA hairpins that fold/unfold under the action of applied mechanical force. We introduce the concept of the molecular free energy…
Force-induced misfolding in RNA
M. Manosas, I. Junier, F. Ritort
RNA folding is a kinetic process governed by the competition of a large number of structures stabilized by the transient formation of base pairs that may induce complex folding pat…
Recovery of free energy branches in single molecule experiments
Ivan Junier, Alessandro Mossa, Maria Manosas +1
We present a method for determining the free energy of coexisting states from irreversible work measurements. Our approach is based on a fluctuation relation that is valid for diss…
Force unfolding kinetics of RNA using optical tweezers. I. Effects of experimental variables on measured results
J. -D. Wen, M. Manosas, P. T. X. Li +4
Experimental variables of optical tweezers instrumentation that affect RNA folding/unfolding kinetics were investigated. A model RNA hairpin, P5ab, was attached to two micron-sized…
Force dependent fragility in RNA hairpins
M. Manosas, D. Collin, F. Ritort
We apply Kramers theory to investigate the dissociation of multiple bonds under mechanical force and interpret experimental results for the unfolding/refolding force distributions…