3 citations · 5 across the 5 of their papers we have counts for
6 papers
Optimal Control of Chemical Reaction Networks with Thermodynamic Cost
Tetsuya J. Kobayashi, Alix Robin, Shuhei A. Horiguchi
Thermodynamic control seeks to realize desired functions at minimal thermodynamic cost, yet existing frameworks remain largely confined to slow driving regimes or state-to-state tr…
Local stabilizability implies global controllability in catalytic reaction systems
Yusuke Himeoka, Shuhei A. Horiguchi, Naoto Shiraishi +2
Controlling complex reaction networks is a fundamental challenge in the fields of physics, biology, and systems engineering. Here, we prove a general principle for catalytic reacti…
Optimal control of stochastic reaction networks with entropic control cost and emergence of mode-switching strategies
Shuhei A. Horiguchi, Tetsuya J. Kobayashi
Controlling the stochastic dynamics of biological populations is a challenge that arises across various biological contexts. However, these dynamics are inherently nonlinear and in…
A theoretical basis for cell deaths
Yusuke Himeoka, Shuhei A. Horiguchi, Tetsuya J. Kobayashi
Understanding deaths and life-death boundaries of cells is a fundamental challenge in biological sciences. In this study, we present a theoretical framework for investigating cell…
Information Geometry of Dynamics on Graphs and Hypergraphs
Tetsuya J. Kobayashi, Dimitri Loutchko, Atsushi Kamimura +2
We introduce a new information-geometric structure associated with the dynamics on discrete objects such as graphs and hypergraphs. The presented setup consists of two dually flat…
Cellular gradient flow structure connects single-cell-level rules and population-level dynamics
Shuhei A. Horiguchi, Tetsuya J. Kobayashi
In multicellular systems, the single-cell behaviors should be coordinated consistently with the overall population dynamics and functions. However, the interrelation between single…