74 citations · 230 across the 14 of their papers we have counts for
15 papers
Assessment of Immune Correlates of Protection via Controlled Vaccine Efficacy and Controlled Risk
Peter B. Gilbert, Youyi Fong, Marco Carone
Immune correlates of protection (CoPs) are immunologic biomarkers accepted as a surrogate for an infectious disease clinical endpoint and thus can be used for traditional or provis…
Efficient nonparametric estimation of the covariate-adjusted threshold-response function, a support-restricted stochastic intervention
Lars van der Laan, Wenbo Zhang, Peter B. Gilbert
Identifying a biomarker or treatment-dose threshold that marks a specified level of risk is an important problem, especially in clinical trials. This risk, viewed as a function of…
Efficient nonparametric inference on the effects of stochastic interventions under two-phase sampling, with applications to vaccine efficacy trials
Nima S. Hejazi, Mark J. van der Laan, Holly E. Janes +2
The advent and subsequent widespread availability of preventive vaccines has altered the course of public health over the past century. Despite this success, effective vaccines to…
A general framework for inference on algorithm-agnostic variable importance
Brian D. Williamson, Peter B. Gilbert, Noah R. Simon +1
In many applications, it is of interest to assess the relative contribution of features (or subsets of features) toward the goal of predicting a response -- in other words, to gaug…
Ongoing Vaccine and Monoclonal Antibody HIV Prevention Efficacy Trials and Considerations for Sequel Efficacy Trial Designs
Peter B. Gilbert
Four randomized placebo-controlled efficacy trials of a candidate vaccine or passively infused monoclonal antibody for prevention of HIV-1 infection are underway (HVTN 702 in South…
Post-randomization Biomarker Effect Modification in an HIV Vaccine Clinical Trial
Peter B. Gilbert, Bryan S. Blette, Bryan E. Shepherd +1
While the HVTN 505 trial showed no overall efficacy of the tested vaccine to prevent HIV infection over placebo, previous studies, biological theories, and the finding that immune…