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stat.ME2025
Poisson process factorization for modeling mutational processes along cancer genomes
Alessandro Zito, Giovanni Parmigiani, Jeffrey W. Miller
Cancer cells acquire DNA mutations through many processes, such as environmental exposures and dysregulated repair mechanisms, and each process consistently produces distinct mutat…
stat.ME2024
Improved control of Dirichlet location and scale near the boundary
Catherine Xue, Alessandro Zito, Jeffrey W. Miller
Dirichlet distributions are commonly used for modeling vectors in a probability simplex. When used as a prior or a proposal distribution, it is natural to set the mean of a Dirichl…
stat.ME2024★ 1 cited
Compressive Bayesian non-negative matrix factorization for mutational signatures analysis
Alessandro Zito, Jeffrey W. Miller
Non-negative matrix factorization (NMF) is a popular tool for dimensionality reduction, especially for count matrices. However, inferring an appropriate number of factors is challe…