184 citations · 344 across the 10 of their papers we have counts for
10 papers
Local migration quantification method for scratch assays
Ana Victoria Ponce Bobadilla, Jazmine Arévalo, Eduard Sarró +6
Motivation: The scratch assay is a standard experimental protocol used to characterize cell migration. It can be used to identify genes that regulate migration and evaluate the eff…
Minimum Action Path theory reveals the details of stochastic biochemical transitions out of oscillatory cellular states
Roberto de la Cruz, Ruben Perez-Carrasco, Pilar Guerrero +2
Cell state determination is the outcome of intrinsically stochastic biochemical reactions. Tran- sitions between such states are studied as noise-driven escape problems in the chem…
3D hybrid modeling of vascular network formation
Holger Perfahl, Barry D Hughes, Tomas Alaracon +4
We develop an agent-based model of vasculogenesis, the de novo formation of blood vessels. Endothelial cells in the vessel network are viewed as linearly elastic spheres and are of…
Stochastic multi-scale models of competition within heterogeneous cellular populations: simulation methods and mean-field analysis
Roberto de la Cruz, Pilar Guerrero, Fabian Spill +1
We propose a modelling framework to analyse the stochastic behaviour of heterogeneous, multi-scale cellular populations. We illustrate our methodology with a particular example in…
The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions
Roberto de la Cruz, Pilar Guerrero, Fabian Spill +1
We analyse the effect of intrinsic fluctuations on the properties of bistable stochastic systems with time scale separation operating under1 quasi-steady state conditions. We first…
Hybrid approaches for multiple-species stochastic reaction-diffusion models
Fabian Spill, Pilar Guerrero, Tomas Alarcon +2
Reaction-diffusion models are used to describe systems in fields as diverse as physics, chemistry, ecology and biology. The fundamental quantities in such models are individual ent…
Mesoscopic and continuum modelling of angiogenesis
Fabian Spill, Pilar Guerrero, Tomas Alarcon +2
Angiogenesis is the formation of new blood vessels from pre-existing ones in response to chemical signals secreted by, for example, a wound or a tumour. In this paper, we propose a…
From gene regulatory networks to population dynamics: robustness, diversity and their role in progression to cancer
Tomas Alarcon, Henrik Jeldtoft Jensen
The aim of this paper is to discuss the role of robustness and diversity in population dynamics in particular to some properties of the multi-step from healthy tissue to fully mali…
Quiescence: a mechanism for escaping the effects of drug on cell populations
Tomas Alarcon, Henrik Jeldtoft Jensen
We point out that a simple and generic strategy to lower the risk for extinction consists in the developing a dormant stage in which the organism is unable to multiply but may die.…
Spreading on a complex network avoiding certain motifs
Tomas Alarcon, Henrik Jeldtoft Jensen
Spreading of either information or matter can often be treated as a network problem. It can be of great importance to be able to estimate the likelihood that spreading through a ne…