4 papers
An immune world model for multiscale forecasting and therapeutic hypothesis generation
Taoyong Cui, Xi Wang, Zonghang Li +11
Immune therapies act across cell-intrinsic programs, tissue ecosystems, and patient-specific immune states, yet most predictors address these scales separately. We used a governed…
ADMET-EvO: a self-evolving scientific agent for sustained research across heterogeneous tasks
Yiling Zhou, Yilin Wang, Jianmin Wang +8
Scientific agents can move beyond automated model building by using accumulated evidence to revise both their questions and experimental strategies. The challenge is sustaining thi…
Proteo-R1: Reasoning Foundation Models for De Novo Protein Design
Fang Wu, Weihao Xuan, Heli Qi +26
Deep learning in de novo protein design has achieved atomic-level fidelity. However, existing models remain largely non-deliberative: they directly synthesize molecular geometries…
Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
Alex Zhavoronkov, Dominika Wilczok
The unprecedented extension of the human lifespan necessitates a parallel evolution in how we quantify the quality of aging and its socioeconomic impact. Traditional metrics focusi…