4 papers
Collective gene dynamics leave signatures of decision landscapes in cell fate coordinates
Maria Yampolskaya, Laertis Ikonomou, Pankaj Mehta
Multicellular organisms contain a wide variety of highly specialized cell types. The consistency and robustness of developmental trajectories suggest that complex gene regulatory n…
What do the fundamental constants of physics tell us about life?
Pankaj Mehta, Jane Kondev
In the 1970s, the renowned physicist Victor Weisskopf famously developed a research program to qualitatively explain properties of matter in terms of the fundamental constants of p…
Randomness with constraints: constructing minimal models for high-dimensional biology
Ilya Nemenman, Pankaj Mehta
Biologists and physicists have a rich tradition of modeling living systems with simple models composed of a few interacting components. Despite the remarkable success of this appro…
Hopfield Networks as Models of Emergent Function in Biology
Maria Yampolskaya, Pankaj Mehta
Hopfield models, originally developed to study memory retrieval in neural networks, have become versatile tools for modeling diverse biological systems in which function emerges fr…