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cs.LG2026
PerturbCellRL: Verifier-Guided Reinforcement Learning for Single-Cell Perturbation Prediction
Dongxia Wu, Mingyu Li, Yuhui Zhang +4
Single-cell perturbation models can reduce costly wet-lab screening by predicting how cells respond transcriptionally to interventions. While recent generative models improve popul…
cs.LG2026
Divide and Learn: Multi-Objective Combinatorial Optimization at Scale
Esha Singh, Dongxia Wu, Chien-Yi Yang +3
Multi-objective combinatorial optimization seeks Pareto-optimal solutions over exponentially large discrete spaces, yet existing methods sacrifice generality, scalability, or theor…
cs.LG2024
MF-LAL: Drug Compound Generation Using Multi-Fidelity Latent Space Active Learning
Peter Eckmann, Dongxia Wu, Germano Heinzelmann +2
Current generative models for drug discovery primarily use molecular docking as an oracle to guide the generation of active compounds. However, such models are often not useful in…