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stat.ME2026
A Cosine-Projection Framework for Choosing Among Cox HR, D-RMST, and Average-Hazard Tests in Survival Trials
Xiang Meng, Lu Tian, Hajime Uno
The log-rank/Cox hazard-ratio test remains the standard approach for the primary analysis of randomized trials with time-to-event endpoints and is fully efficient under proportiona…
stat.ME2026
Average Cause-Specific Hazard: A Censoring-Invariant Measure of Event Burden Under Competing Risks
Khondoker Nazmoon Nabi, Xiang Meng, Lu Tian +3
Competing events are common in clinical and epidemiologic studies, including semi-competing risks in which a terminal event such as death may follow a nonfatal event but also compe…
stat.ME2026
Efficient and Debiased Learning of Average Hazard Under Non-Proportional Hazards
Xiang Meng, Lu Tian, Kenneth Kehl +1
The hazard ratio from the Cox proportional hazards model is a ubiquitous summary of treatment effect. However, when hazards are non-proportional, the hazard ratio can lose a stable…