61 citations · 70 across the 8 of their papers we have counts for
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stat.ME2019★ 2 cited
Effect of Interim Adaptations in Group Sequential Designs
Sergey Tarima, Nancy Flournoy
This manuscript investigates unconditional and conditional-on-stopping maximum likelihood estimators (MLEs), information measures and information loss associated with conditioning…
stat.ME2019★ 1 cited
Random Norming Aids Analysis of Non-linear Regression Models with Sequential Informative Dose Selection
Zhantao Lin, Nancy Flournoy, William F. Rosenberger
A two-stage adaptive optimal design is an attractive option for increasing the efficiency of clinical trials. In these designs, based on interim data, the locally optimal dose is c…