61 citations · 70 across the 8 of their papers we have counts for
6 papers · 1 filter
The Cost of Sequential Adaptation and the Lower Bound for Mean Squared Error
Sergey Tarima, Nancy Flournoy
Informative interim adaptations lead to random sample sizes. The random sample size becomes a component of the sufficient statistic and estimation based solely on observed samples…
Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
Kelly Van Lancker, Sergey Tarima, Jonathan Bartlett +8
The COVID-19 pandemic continues to affect the conduct of clinical trials globally. Complications may arise from pandemic-related operational challenges such as site closures, trave…
Most Powerful Test Sequences with Early Stopping Options
Sergey Tarima, Nancy Flournoy
Sequential likelihood ratio testing is found to be most powerful in sequential studies with early stopping rules when grouped data come from the one-parameter exponential family. F…
Effect of Interim Adaptations in Group Sequential Designs
Sergey Tarima, Nancy Flournoy
This manuscript investigates unconditional and conditional-on-stopping maximum likelihood estimators (MLEs), information measures and information loss associated with conditioning…
Random Norming Aids Analysis of Non-linear Regression Models with Sequential Informative Dose Selection
Zhantao Lin, Nancy Flournoy, William F. Rosenberger
A two-stage adaptive optimal design is an attractive option for increasing the efficiency of clinical trials. In these designs, based on interim data, the locally optimal dose is c…
Centered Isotonic Regression: Point and Interval Estimation for Dose-Response Studies
Assaf P. Oron, Nancy Flournoy
Univariate isotonic regression (IR) has been used for nonparametric estimation in dose-response and dose-finding studies. One undesirable property of IR is the prevalence of piecew…