43 citations · 101 across the 7 of their papers we have counts for
8 papers
Machine Learning Study of the Extended Drug-target Interaction Network informed by Pain Related Voltage-Gated Sodium Channels
Long Chen, Jian Jiang, Bozheng Dou +6
Pain is a significant global health issue, and the current treatment options for pain management have limitations in terms of effectiveness, side effects, and potential for addicti…
TIDAL: Topology-Inferred Drug Addiction Learning
Zhu Zailiang, Dou Bozheng, Cao Yukang +8
Drug addiction or drug overdose is a global public health crisis, and the design of anti-addiction drugs remains a major challenge due to intricate mechanisms. Since experimental d…
Hopf Bifurcation in Mean Field Explains Critical Avalanches in Excitation-Inhibition Balanced Neuronal Networks: A Mechanism for Multiscale Variability
Junhao Liang, Tianshou Zhou, Changsong Zhou
Cortical neural circuits display highly irregular spiking in individual neurons but variably sized collective firing, oscillations and critical avalanches at the population level,…
Exact distributions for stochastic models of gene expression with arbitrary regulation
Zihao Wang, Zhenquan Zhang, Tianshou Zhou
Stochasticity in gene expression can result in fluctuations in gene product levels. Recent experiments indicated that feedback regulation plays an important role in controlling the…
Non-trivial Resource Amount Requirement in the Early Stage for Containing Fatal Diseases
Xiaolong Chen, Tianshou Zhou, Ling Feng +4
During an epidemic control, the containment of the disease is usually achieved through increasing devoted resource to shorten the duration of infectiousness. However, the impact of…
Geometric Characteristics of Dynamic Correlations for Combinatorial Regulation in Gene Expression Noise
Jiajun Zhang, Zhanjiang Yuan, Tianshou Zhou
Knowing which mode of combinatorial regulation (typically, AND or OR logic operation) that a gene employs is important for determining its function in regulatory networks. Here, we…