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q-bio.QM2026
DrugGen 2: A disease-aware language model for enhancing drug discovery
Ali Motahharynia, Mohammadreza Ghaffarzadeh-Esfahani, Mahsa Sheikholeslami +4
Current computational approaches for drug design typically focus on generating molecules conditioned on specific targets or general molecular properties, often neglecting the influ…
q-bio.QM2026
AAVGen: Precision Engineering of Adeno-associated Viral Capsids for Renal Selective Targeting
Mohammadreza Ghaffarzadeh-Esfahani, Yousof Gheisari
Adeno-associated viruses (AAVs) are promising vectors for gene therapy, but their native serotypes face limitations in tissue tropism, immune evasion, and production efficiency. En…