115 citations · 237 across the 7 of their papers we have counts for
7 papers
Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
Thi-Huong Nguyen, Nikolay Medvedev, Mihaela Delcea +1
Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4-CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of…
Rupture Forces among Human Blood Platelets at different Degrees of Activation
Thi-Huong Nguyen, Raghavendra Palankar, Van-Chien Bui +3
Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological…
Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes
Una Janke, Martin Kulke, Ina Buchholz +3
Integrins are transmembrane proteins involved in hemostasis, wound healing, immunity and cancer. In response to intracellular signals and ligand binding, integrins adopt different…
Interaction of fibrinogen-magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes
Ulrike Martens, Una Janke, Sophie Moeller +3
Magnetic nanoparticles have a broad spectrum of biomedical applications including cell separation, diagnostics and therapy. One key issue is little explored: how do the engineered…
Lysine residues control the conformational dynamics of beta 2-glycoprotein I
Ina Buchholz, Peter Nestler, Susan Köppen +1
One of the major problems in the study of the dynamics of proteins is the visualization of changing conformations that are important for processes ranging from enzyme catalysis to…
The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant
Ina Buchholz, Felix Nagel, Annelie Klein +6
One of the most common mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene is the N34S variant which is strongly associated with chronic pancreatitis. Although it…