2 papers
stat.AP2026
Estimands and the Choice of Non-Inferiority Margin under ICH E9(R1)
Tobias Mütze, Helle Lynggaard, Sunita Rehal +3
Since the release of the ICH E9(R1) addendum on estimands, its application in non-inferiority trials has received far less attention than in superiority settings. A key conclusion…
stat.AP2025
Incorporating estimands into meta-analyses of clinical trials
Antonio Remiro-Azócar, Pepa Polavieja, Emmanuelle Boutmy +9
The estimand framework is increasingly established to pose research questions in confirmatory clinical trials. In evidence synthesis, the uptake of estimands has been modest, and t…