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q-bio.BM2009★ 100 cited
How accurate are polymer models in the analysis of Forster resonance energy transfer experiments on proteins?
E. P. O'Brien, G. Morrison, B. R. Brooks +1
Single molecule Forster resonance energy transfer (FRET) experiments are used to infer the properties of the denatured state ensemble (DSE) of proteins. From the measured average F…
q-bio.BM2009★ 2 cited
Molecular origin of constant m-values, denatured state collapse, and residue-dependent transition midpoints in globular proteins
Edward P. O'Brien, Bernard R. Brooks, Dave Thirumalai
Experiments show that for many two state folders the free energy of the native state DG_ND([C]) changes linearly as the denaturant concentration [C] is varied. The slope, m = d DG_…