4 papers
Collective Cell Fluidity Controls Active Prestress Transmission in Cell-Extracellular-Matrix Tissues
Liyang Wang, J. M. Schwarz, Tao Zhang
Tissues are active composites in which multicellular collectives and extracellular matrices mechanically reorganize one another. We develop a three-dimensional micromechanical mode…
Learning Associations in Reconfigurable Particle Packings via Local Cyclic Driving
Wenjing Guo, Vidyesh Rao Anisetti, Kairui Zhang +7
We investigate associative-memory behavior in a reconfigurable particle packing programmed by purely local cyclic driving. The system is a two-dimensional bidisperse Lennard--Jones…
Cell strain-stiffening drives cell breakout from embedded spheroids
Shabeeb Ameen, Kyungeun Kim, Ligesh Theeyancheri +5
Understanding how cells escape from embedded spheroids requires a mechanical framework linking stress generation within cells, across cells, and between cells and the surrounding e…
Enhanced extracellular matrix remodeling due to embedded spheroid fluidization
Tao Zhang, Shabeeb Ameen, Sounok Ghosh +5
Tumor spheroids are in vitro three-dimensional, cellular collectives consisting of cancerous cells. Embedding these spheroids in an in vitro fibrous environment, such as a collagen…