4 papers
Kinetic Interference in Translational Control: A Path-Measure Framework for Collision-Triggered Transcript Decay
Shlomo Segal
I connect two literatures developed independently: the path-measure formulation of non-equilibrium statistical mechanics, where a trajectory action decomposes into a time-antisymme…
Channel selection at identically vanishing dissipation difference: isolating the frenetic sector of the overdamped path measure
Shlomo Segal
Transition-state and Kramers-Langer theory determine reaction channel selection from data at a single point: the saddle. We show this is insufficient in a precise, constructive sen…
Geometric Dissipation Constraints in Stochastic Reaction Dynamics: A Variational Observable for Hidden Kinetic Structure in Energy Landscapes
Shlomo Segal
We propose a geometric framework for characterizing hidden kinetic constraints in stochastic reaction dynamics. While free-energy barriers and entropy production provide global des…
A Formal Physical Framework for the Origin of Life: Dissipation-Driven Selection of Evolving Replicators
Shlomo Segal
The emergence of life from inanimate matter presents a thermodynamic challenge: the Second Law of Thermodynamics dictates a global trend towards disorder, yet life constitutes loca…