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stat.ME2026
Beyond the Composite: Enhancing Trial Analysis through a Divide & Conquer Approach to 'Days Alive and at Home': Insights from the NOTACS trial
Letao Yuan, SofÃa S. Villar, Dominique-Laurent Couturier
"Days alive and at home" (DAH) is a recent patient-centered outcome measure for perioperative trials, defined as the number of days a patient spends at home during the follow-up pe…
stat.ME2026
Component over Composite: Mitigating Type I Error Inflation when Imputing "Days Alive and at Home"
Mia S. Tackney, Sarah Dawson, Letao Yuan +2
Background: Days Alive and at Home (DAH) over a pre-defined follow-up period is a novel post-intervention composite outcome that combines data from at least three components: (i) i…
stat.ME2026
Operationalizing Allocation Probability Tests: Practical Guidance on Optimized Implementation for Power and Robustness
Stina Zetterstrom, David S. Robertson, Thomas Jaki +1
Recently, a new testing approach for response-adaptive clinical trials was proposed based on the allocation probabilities (AP) rather than the outcome data. While original work on…