7 papers
ConceptMoE: Concept-Guided Multimodal Mixture of Experts for Interpretable Computational Pathology
Xuan Wang, Zhongling Xu, Gopi Kannedhara +13
Healthcare models are transitioning from unimodal prediction toward multimodal reasoning over heterogeneous diagnostic inputs. In computational pathology, for complex tumor subtype…
Mixture of Mini Experts: Overcoming the Linear Layer Bottleneck in Multiple Instance Learning
Daniel Shao, Joel Runevic, Richard J. Chen +4
Multiple Instance Learning (MIL) is the predominant framework for classifying gigapixel whole-slide images in computational pathology. MIL follows a sequence of 1) extracting patch…
Towards Spatial Transcriptomics-driven Pathology Foundation Models
Konstantin Hemker, Andrew H. Song, Cristina Almagro-Pérez +6
Spatial transcriptomics (ST) provides spatially resolved measurements of gene expression, enabling characterization of the molecular landscape of human tissue beyond histological a…
Do Multiple Instance Learning Models Transfer?
Daniel Shao, Richard J. Chen, Andrew H. Song +4
Multiple Instance Learning (MIL) is a cornerstone approach in computational pathology (CPath) for generating clinically meaningful slide-level embeddings from gigapixel tissue imag…
A Foundation Model for Spatial Proteomics
Muhammad Shaban, Yuzhou Chang, Huaying Qiu +57
Foundation models have begun to transform image analysis by acting as pretrained generalist backbones that can be adapted to many tasks even when post-training data are limited, ye…
AI-driven 3D Spatial Transcriptomics
Cristina Almagro-Pérez, Andrew H. Song, Luca Weishaupt +13
A comprehensive three-dimensional (3D) map of tissue architecture and gene expression is crucial for illuminating the complexity and heterogeneity of tissues across diverse biomedi…