4 papers
Fast Computational Methods for Regularized Estimating Equations
Weihua Shi, Yixuan Li, Yi Lian +2
Estimating equations arise in a wide range of statistical applications, including longitudinal and clustered data analysis, survival analysis, econometrics, and semiparametric infe…
Robust Mendelian Randomization Estimation using Weighted Quantile Regression
Julien St-Pierre, Archer Y. Yang, Mireille E. Schnitzer +1
In Mendelian randomization (MR) studies, genetic variants are used as instrumental variables (IVs) to investigate causal relationships between exposures and outcomes based on obser…
Disentangling Shared and Target-Enriched Topics via Background-Contrastive Non-negative Matrix Factorization
Yixuan Li, Archer Y. Yang, Yue Li
Biological signals of interest in high-dimensional data are often masked by dominant variation shared across conditions. This variation, arising from baseline biological structure…
MixEHR-SurG: a joint proportional hazard and guided topic model for inferring mortality-associated topics from electronic health records
Yixuan Li, Archer Y. Yang, Ariane Marelli +1
Survival models can help medical practitioners to evaluate the prognostic importance of clinical variables to patient outcomes such as mortality or hospital readmission and subsequ…