Showing q-bio.QMShow all
2 papers · 1 filter
q-bio.QM2026
Structure-Aware Prediction of PROTAC-Mediated Protein Degradability via Graph Neural Networks
Bryan Cheng, Austin Jin
Proteolysis-targeting chimeras (PROTACs) can selectively degrade disease-causing proteins, yet predicting which targets are amenable to degradation remains a critical bottleneck: e…
q-bio.QM2026
SpliceBind: Isoform-Aware Prediction of Binding Pocket Druggability
Bryan Cheng, Austin Jin, Joshua Chang
Splice-mediated drug resistance occurs in up to 40% of patients on targeted kinase inhibitors, yet state-of-the-art druggability tools operate on single structures and cannot compa…