Calibrated Abstention for Reliable TCR--pMHC Binding Prediction under Epitope Shift

Arman Bekov, Timur Bekzhanov, Bekzat Sadykov

Predicting T-cell receptor (TCR)--peptide-MHC (pMHC) binding is central to vaccine design and T-cell therapy, yet deployed models frequently encounter epitopes unseen during traini…