31 citations · 43 across the 3 of their papers we have counts for
4 papers
ConforNets: Latents-Based Conformational Control in OpenFold3
Minji Lee, Colin Kalicki, Minkyu Jeon +3
Models from the AlphaFold (AF) family reliably predict one dominant conformation for most well-ordered proteins but struggle to capture biologically relevant alternate states. Seve…
How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities
Charlotte Bunne, Yusuf Roohani, Yanay Rosen +39
The cell is arguably the most fundamental unit of life and is central to understanding biology. Accurate modeling of cells is important for this understanding as well as for determ…
Out of Many, One: Designing and Scaffolding Proteins at the Scale of the Structural Universe with Genie 2
Yeqing Lin, Minji Lee, Zhao Zhang +1
Protein diffusion models have emerged as a promising approach for protein design. One such pioneering model is Genie, a method that asymmetrically represents protein structures dur…
Generating Novel, Designable, and Diverse Protein Structures by Equivariantly Diffusing Oriented Residue Clouds
Yeqing Lin, Mohammed AlQuraishi
Proteins power a vast array of functional processes in living cells. The capability to create new proteins with designed structures and functions would thus enable the engineering…